Host genetic determinants of influenza pathogenicity
نویسندگان
چکیده
منابع مشابه
Genetic determinants for infectivity and pathogenicity of influenza viruses.
The objective of the studies presented was to define a molecular basis for infectivity and pathogenicity of influenza virus. It is demonstrated that activation of the HA glycoprotein by post-translational proteolytic cleavage is indispensable for the formation of infectious influenza virus. There are two preconditions for influenza virus to be pathogenic: (1) the presence on the virus particle ...
متن کاملGenetic determinants for infectivity and pathogenicity of influenza viruses
The objective of the studies presented was to define a molecular basis for infectivity and pathogenicity of influenza virus. It is demonstrated that activation of the HA glycoprotein by post-translational proteolytic cleavage is indispensable for the formation of infectious influenza virus. There are two preconditions for influenza virus to be pathogenic: (1) the presence on the virus particle ...
متن کاملInfluenza: viral determinants of the pathogenicity and epidemicity of an invariant disease of variable occurrence.
If influenza is a riddle wrapped in mystery inside an enigma, then the viral genes are the riddle, the variable surface antigens for which they code are the mystery, and the course and cause of epidemics the ultimate enigma. Paradoxically, the disease itself has remained a stable and recognizable entity through the years, whether initiated by A/PR/8/34 or A/USSR/90/77 variant viruses. Thus, evo...
متن کاملElevation of CpG frequencies in influenza A genome attenuates pathogenicity but enhances host response to infection
Previously, we demonstrated that frequencies of CpG and UpA dinucleotides profoundly influence the replication ability of echovirus 7 (Tulloch et al., 2014). Here, we show that that influenza A virus (IAV) with maximised frequencies of these dinucleotides in segment 5 showed comparable attenuation in cell culture compared to unmodified virus and a permuted control (CDLR). Attenuation was also m...
متن کاملHost Range Restriction and Pathogenicity in the Context of Influenza Pandemic
Influenza A viruses cause pandemics at random intervals. Pandemics are caused by viruses that contain a hemagglutinin (HA) surface glycoprotein to which human populations are immunologically naive. Such an HA can be introduced into the human population through reassortment between human and avian virus strains or through the direct transfer of an avian influenza virus to humans. The factors tha...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Current Opinion in Virology
سال: 2013
ISSN: 1879-6257
DOI: 10.1016/j.coviro.2013.07.005